Ja. Moreno et al., INHIBITION OF D-AMINO-ACID OXIDASE BY ALPHA-KETO ACIDS ANALOGS OF AMINO-ACIDS, Enzyme and microbial technology, 18(5), 1996, pp. 379-382
The inhibition D-amino acid oxidase by certain alpha-keto acids produc
ts of the reaction with D-amino acids, in particular oc-keto acids tha
t are analogs of the amino acids alanine, valine, leucine, phenylanali
ne, phenylglycine, tyrosine and tryptophan, is reported All the alpha-
keto acids assayed behaved as substrate competitive inhibitors of the
enzyme. The relationship between the degree of inhibition and the stru
cture of the inhibitor is discussed.