INHIBITION OF D-AMINO-ACID OXIDASE BY ALPHA-KETO ACIDS ANALOGS OF AMINO-ACIDS

The inhibition D-amino acid oxidase by certain alpha-keto acids produc ts of the reaction with D-amino acids, in particular oc-keto acids tha t are analogs of the amino acids alanine, valine, leucine, phenylanali ne, phenylglycine, tyrosine and tryptophan, is reported All the alpha- keto acids assayed behaved as substrate competitive inhibitors of the enzyme. The relationship between the degree of inhibition and the stru cture of the inhibitor is discussed.