PRELIMINARY-REPORT - THE SHORT-TERM EFFECTS OF DIRECT P53 DNA INJECTION IN PRIMARY HEPATOCELLULAR CARCINOMAS

Authors
HABIB NA DING SF ELMASRY R MITRY RR HONDA K MICHAIL NE DALLASERRA G IZZI G GRECO L BASSYOUNI M ELTOUKHY M ABDELGAFFAR Y
Citation
Na. Habib et al., PRELIMINARY-REPORT - THE SHORT-TERM EFFECTS OF DIRECT P53 DNA INJECTION IN PRIMARY HEPATOCELLULAR CARCINOMAS, Cancer detection and prevention, 20(2), 1996, pp. 103-107
Citations number
13
Categorie Soggetti
Oncology
Journal title
Cancer detection and prevention → ACNP
ISSN journal
0361090X
Volume
20
Issue
2
Year of publication
1996
Pages
103 - 107
Database
ISI
SICI code
0361-090X(1996)20:2<103:P-TSEO>2.0.ZU;2-D
Abstract
A pilot study, to assess the therapeutic potential of percutaneous inj ection of wild-type p53 (wt-p53) in five patients with primary hepatoc ellular carcinoma is reported. Three of the five patients showed objec tive tumor response with reduction of the tumor volume on computed tom ographic (CT) scan measurements as well as a significant fall of serum alphafetoprotein. Much further work will be needed to elucidate the m echanism of action.