CYTOGENETIC EVIDENCE THAT CARCINOMA IN-SITU IS THE PRECURSOR LESION FOR INVASIVE TESTICULAR GERM-CELL TUMORS

Authors
VANECHTEN J VANGURP RJHLM STOEPKER M LOOIJENGA LHJ DEJONG B OOSTERHUIS JW
Citation
J. Vanechten et al., CYTOGENETIC EVIDENCE THAT CARCINOMA IN-SITU IS THE PRECURSOR LESION FOR INVASIVE TESTICULAR GERM-CELL TUMORS, Cancer genetics and cytogenetics, 85(2), 1995, pp. 133-137
Citations number
23
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
85
Issue
2
Year of publication
1995
Pages
133 - 137
Database
ISI
SICI code
0165-4608(1995)85:2<133:CETCII>2.0.ZU;2-O
Abstract
A cytogenetic study of two cases of carcinoma in situ of the testis (C IS) and their adjacent invasive tumors, one a nonseminomatous germ cel l tumor (NS) and one a seminoma (SE), revealed similarities in chromos omal pattern between the CIS and the invasive lesion in the same patie nt. These findings present for the first time cytogenetic evidence tha t CIS of the testis and its adjacent germ cell tumor are clonally rela ted, which suggests that the CIS is indeed the precursor lesion of the invasive tumor.