METHOD TO STUDY THE SEPARATION OF 8 P-HYDROXYBENZOIC ESTERS BY GAS-CHROMATOGRAPHY

A model to predict gas chromatographic retention indices from molecula r structure and Derringer and Suich's approach were used to study the separation of eight p-hydroxybenzoic esters. The optimization method c onnects a general simplex method to a computer. A simplex difactor (co lumn temperature/gas flow-rate) optimization-gas chromatography (SDO-G C) method was developed. More than half the number of experiments requ ired in the general simplex method were omitted. Good agreement was ob tained between predicted and experimental results.