USE OF ANTI-NEUROFILAMENT ANTIBODY TO IDENTIFY PAIRED-HELICAL FILAMENTS IN INCLUSION-BODY MYOSITIS

Authors
ASKANAS V ALVAREZ RB MIRABELLA M ENGEL WK
Citation
V. Askanas et al., USE OF ANTI-NEUROFILAMENT ANTIBODY TO IDENTIFY PAIRED-HELICAL FILAMENTS IN INCLUSION-BODY MYOSITIS, Annals of neurology, 39(3), 1996, pp. 389-391
Citations number
10
Categorie Soggetti
Clinical Neurology",Neurosciences
Journal title
Annals of neurology → ACNP
ISSN journal
03645134
Volume
39
Issue
3
Year of publication
1996
Pages
389 - 391
Database
ISI
SICI code
0364-5134(1996)39:3<389:UOAATI>2.0.ZU;2-5
Abstract
Paired-helical filaments (PHFs) are an important diagnostic criterion of the inclusion-body myositis (IBM) muscle biopsy; but, until now, th eir presence could be identified only by electronmicroscopy. In this r eport, we describe an easy immunocytochemical procedure, utilizing com mercially available antibody, that enables reliable identification of muscle PHFs by light microscopy. This procedure greatly facilitates di agnosis of IBM.