In contemporary psychosocial treatment research, the test of the effic
acy of standardized treatment manuals predominates in respectability r
elative to naturalistic research on the process components of flexible
treatments, though the latter strategy is necessary for the empirical
identification of effective process components. Standardizing a treat
ment constrains the variance of process variables and, thereby, attenu
ates the manifestation of potential correlations. Research is reviewed
, providing evidence for several unexpected deleterious or moderating
effects of utilizing standardized treatment manuals. We conclude that
naturalistic research using flexible treatments is necessary for makin
g the development of treatment manuals, and their modification, a trul
y scientific process.