NEW ISOCHROMOPHILONE-VII AND ISOCHROMOPHILONE-VIII PRODUCED BY PENICILLIUM SP FO-4164

Authors
YANG DJ TOMODA H TABATA N MASUMA R OMURA S
Citation
Dj. Yang et al., NEW ISOCHROMOPHILONE-VII AND ISOCHROMOPHILONE-VIII PRODUCED BY PENICILLIUM SP FO-4164, Journal of antibiotics, 49(3), 1996, pp. 223-229
Citations number
20
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
49
Issue
3
Year of publication
1996
Pages
223 - 229
Database
ISI
SICI code
0021-8820(1996)49:3<223:NIAIPB>2.0.ZU;2-T
Abstract
New isochromophilones VII and VIII were isolated from the culture brot h of Penicillium sp. FO-4164. The structures were elucidated as 6H-2-b enzopyran-6,8(7H)-dione, adienyl)-1,7,8a-trihydro-7,8a-dihydroxy-7-met hyl-7 for isochrornophilone VII and 7,8,8a-tetrahydro-7,8-dihydroxy-7- methyl-8-acetate for isochromophilone VIII. Isochromophiloncs VII and VIII inhibited diacylglycerol acyltransferase activity with IC50 value s of 20.0 and 127 mu M and acyl-CoA: cholesterol acyltransferase activ ity with IC50 values of 24.5 and 47.0 mu M, respectively.