QUINOXAPEPTINS - NOVEL CHROMODEPSIPEPTIDE INHIBITORS OF HIV-1 AND HIV-2 REVERSE-TRANSCRIPTASE .1. THE PRODUCING ORGANISM AND BIOLOGICAL-ACTIVITY

Quinoxapeptin A and B are novel chromodepsipeptides which were isolate d from a nocardioform actinomycete with indeterminant morphology. Quin oxapeptins a and B are potent inhibitors of HIV-1 and HIV-2 reverse tr anscriptase and almost equally active against two single mutants forms as well as a double mutant form of HIV-1 reverse transcriptase. Quino xapeptin A and B are specific inhibitors of HIV-I and HIV-2 reverse tr anscriptase because they did not inhibit human DNA polymerase alpha, b eta, gamma, and delta. Quinoxapeptin A and B are structurally similar to luzopeptin A which was also active against HIV-land HIV-2 reverse t ranscriptase.