GNRH GENE-EXPRESSION IN NEURONAL CELL-LINES

Little is known about the mechanisms that subserve GnRH synthesis. The recent availability of clonal populations of GnRH neurons enables us for the first time to examine the structural organization of the GnRH locus, Studies are underway to dissect the manner in which neural spec ific expression and developmental regulation of GnRH are programmed. T hese studies will complement and provide direction to future animal st udies designed to better understand the control of GnRH gene expressio n.