PLASMA 1,5-ANHYDRO-D-GLUCITOL CONCENTRATION AND ITS RELATION TO OTHERPLASMA COMPONENTS IN RENAL-FAILURE AND RENAL-TRANSPLANT RECIPIENTS

Plasma levels of 1,5-anhydro-D-glucitol (AG) were measured in non-diab etic patients with renal failure or following renal transplant. For pa tients with renal failure (n = 20) from various causes, the plasma lev el of AG was found to be positively associated with urate and negative ly with both urea and prior dialysis. The results for seven renal tran splant recipients, serially assessed during the post-transplant period , verified an increase in plasma AG with time, approaching normal leve ls (greater than or equal to 70 mu mol/l) after 60 days, and which was adversely affected by rejection episodes, The actual mean rate of pla sma AG rise ranged from 0.35 to 1.29 mu mol/l per day, AG levels for l ong term (>1000 days) surviving renal transplant recipients (n = 16) w ere predominantly related to renal function as assessed by plasma crea tinine.