SECONDARY AMENORRHEA AFTER TOTAL-BODY IRRADIATION IN PRE-PUBERTY

Bone marrow transplant (BMT) has been used as part of the overall trea tment of refractory malignant diseases. High dose cyclophosphamide and total body irradiation (TBI) are frequently used as conditioning for BMT. Initial regimens included a single fraction of TBI, with doses va rying from 7.5-10 Gy, but this was associated with a high incidence of late sequelae including multiple endocrinopathies(1). A fractionated irradiation course over 3-4 days of a higher total dose, 12-15 Gy, of TBI is now used(1,2). Successfully treated patients with childhood can cer have an increased risk, of developing second tumours. We describe a patient successfully treated for AML who developed multiple endocrin e dysfunction and a second benign ovarian tumour.