COMPARISON OF THE SATIATING EFFECT OF THE CCKA RECEPTOR AGONIST A71375 WITH CCK-8S

The satiating effect of the selective cholecystokinin, (CCKA) receptor agonist A71378 and the mixed a and B receptor agonist CCK-8S were com pared in 24-h food-deprived rats. After systemic application of 1.6, 8 .0, and 40 mu g/kg A71378 or CCK-8S, respectively, food intake was mea sured for 24 h. During the first hour A71378 and CCK-8S decreased food intake similarly. Two and 4 h after treatment, the satiating effect o f A71378 continued. In contrast, 2 h after administration of CCK-8S a slight effect was observed at the highest dose (40 mu g/kg), which tot ally disappeared after 4 h. In summary, the effect of A71378 on food i ntake is longer lasting compared to CCK-8S.