Na. Spry et al., ORCHIECTOMY PRIOR TO DEFINITIVE RADIOTHERAPY FOR LOCALIZED PROSTATIC-CANCER, International journal of radiation oncology, biology, physics, 34(5), 1996, pp. 1045-1053
Citations number
40
Categorie Soggetti
Oncology,"Radiology,Nuclear Medicine & Medical Imaging
Purpose: To identify potential survival benefits of cytoreductive orch
idectomy performed prior to definitive radiation for localized prostat
e cancer. Methods and Materials: Between 1977-1988, all patients with
localized prostatic cancer from the Wellington Region received definit
ive radiotherapy (n = 200). One referring urologist Peter M. Meffen (P
.M.M.) had commenced a program of prior orchidectomy followed by defin
itive radiation treatment (median time to radiation therapy was 5 mont
hs, n = 30). Results: Five-year overall survival (OS) and relapse-free
survival (RFS) for each stage were Stage A 82%, and 82%; Stage B 75%,
and 61%; Stage C 57%, and 38%, respectively. Ten-year OS and RFS for
each stage were Stage A 78%, and 72%; Stage B 51%, and 18%; Stage C 32
% and 0%, respectively. Multivariate analysis identified prior orchide
ctomy treatment and histological grade as independently significant pr
ognostic factors for OS and RFS. Factors influencing RFS were clinical
stage, prior orchidectomy, and histological grade. Prior orchidectomy
was associated with an increase in OS at 5 years when compared to tho
se patients receiving radiotherapy alone, 86% vs. 69%, and maintained
at 10 years, 82% vs. 46% (p < 0.05). The two groups were comparable by
stage, histological grade, and age. There were no changes in the refe
rral pattern during the study period. Conclusions: Our results suggest
that prior cytoreduction by orchidectomy has a beneficial effect on O
S and RFS for patients with localized prostate cancer. It is unclear w
hether survival benefits are due to the cytoreductive therapy, the adj
uvant therapy, or a combination of both. Further study in this area is
warranted, ideally in the form of randomized prospective clinical tri
als.