STABILITY AND COMPATIBILITY OF 2.5 MG ML METHOTREXATE SOLUTION IN PLASTIC SYRINGES OVER 7 DAYS/

The physico-chemical stability and the compatibility between a 2.5-mg/ ml methotrexate solution and plastic syringes were studied over a 7 da y period at +4 and 25 degrees C. During this study, pH was determined and MTX degradation products were assayed by HPLC. The compatibility s tudy consisted of the titration of reducing substances, TLC of extract ed additives, assay of extracted ions by AAS, resistivity measurement, dynamometric test and UV, visible and IR absorption spectrophotometry . Stability and compatibility studies showed that 2.5 mg/ml methotrexa te parenteral solution remained chemically stable in a plastic syringe over a period of 7 days under the tested conditions.