NEURONAL MIGRATION DISORDERS PRESENTING WITH MILD CLINICAL SYMPTOMS

Two children with neuronal migration disorders and unexpectedly mild c linical symptoms are reported. The first patient was followed with the diagnosis of febrile convulsion and seizures associated with fever fo r 14 years. Computed tomography scans were normal. Although periodic s low waves of the left parietal cortex were detected on the first two e lectroencephalograms, his latest examination was normal, Magnetic reso nance imaging performed at 16 years of age disclosed a left parietal s chizencephaly extending between the parietal cortex and corpus callosu m. The second patient was followed with the diagnosis of febrile convu lsion for 2 years and later experienced afebrile seizures. On his late st visit, a posterior parietal pachygyric region and a parieto-occipit al island heterotopia on the left hemisphere were diagnosed by magneti c resonance imaging. We believe that review of these patients, at the mildest end of the clinical spectrum of neural migration disorders, wi ll contribute to a new understanding of the correlation between clinic al and pathologic findings of neuronal migration disorders.