SOLID-PHASE ORGANIC-REACTIONS - A REVIEW OF THE RECENT LITERATURE

Combinatorial chemistry has emerged as a powerful new technology for c hemists to synthesise large numbers of compounds for biological evalua tion. One of the techniques used in combinatorial chemistry is polymer supported or ''solid-phase'' organic synthesis. This article reviews the main chemical reactions reported between 1992-October 1995 using s olid-phase support, focusing upon those suitable for synthesising smal l molecules. The reactions are presented in graphical format in a tabl e according to reaction types. Examples presented include amide bond f ormation, aromatic substitutions, condensations, cycloadditions, diazo tisation, enzymatic coupling, use of Grignard reagents, Michael additi ons, multiple component reactions, nucleophilic substitution, olefinat ion, oxidations, protection/deprotection, reduction, immobilisation an d cleavage. Finally, the information presented is evaluated briefly an d some trends are discussed.