THE SYNTHESIS OF THE NOVEL ADENOSINE AGONISTS, EXO-N-6-(5,6-EPOXYNORBORN-2-YL)ADENOSINE AND ENDO-N-6-(5,6-EPOXYNORBORN-2-YL)ADENOSINE

Authors
SCAMMELLS PJ BAKER SP BELLARDINELLI L OLSSON RA RUSSELL RA WRIGHT DMJ
Citation
Pj. Scammells et al., THE SYNTHESIS OF THE NOVEL ADENOSINE AGONISTS, EXO-N-6-(5,6-EPOXYNORBORN-2-YL)ADENOSINE AND ENDO-N-6-(5,6-EPOXYNORBORN-2-YL)ADENOSINE, Tetrahedron, 52(13), 1996, pp. 4735-4744
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
52
Issue
13
Year of publication
1996
Pages
4735 - 4744
Database
ISI
SICI code
0040-4020(1996)52:13<4735:TSOTNA>2.0.ZU;2-J
Abstract
Both racemic exo and endo isomers of N-6-(5,6-epoxynorborn-2-yl)adenos ine have been synthesised and shown to be potent agonists for the Al a denosine receptor. Crucial to the preparation of these compounds is th e synthesis of exo and endo norbornenylamines which are accessed throu gh an optimised Curtius rearrangement.