EXPRESSION OF KI-67 BY MONOCLONAL-ANTIBODY MIB-1 IN CARCINOMA OF THE MIDDLE AND LOWER BILE-DUCT

To evaluate the relationship between cell proliferation and clinical o utcome of bile duct carcinoma, MIB-1 immunohistochemistry and clinicop athological study mere performed in 21 patients who underwent resectio n of carcinoma of the middle and lower bile duct. Some histological fa ctors, especially pancreatic infiltration affected survivals. MIB-1 sc ores (percentages of MIB-1 positive cells) tended to be higher in the patients who died within three years after operations than in the grou p that survived over three years. No relationship was observed between MIB-1 scores and histological tumor spread. These results suggest tha t MIB-1 scores may be useful to predict the clinical outcome of the pa tients with carcinoma of the bile duet, independently of histological tumor spread.