SPECTROPHOTOMETRIC SIMULTANEOUS ANALYSIS OF ANALGIN-ADAMON MIXTURE ININJECTION PREPARATIONS

A new method is described for analyzing a binary mixture of analgin an d adamon using extractive and derivative spectrophotometry. In the met hod, analgin and adamon both were extracted into chloroform as an ion- pair with thymol blue from their aqueous solution buffered to pH 3.6. Determination of these drugs was performed by reading the dA/d lambda values at 600.0 nm and 310.5 nm in the first derivative spectra of the chloroform layer. Relative standard deviations of the method are 0.10 % for analgin and 0.81% for adamon. The method was successfully applie d to an injection solution containing these two active ingredients.