EXTRACTIVE SPECTROPHOTOMETRIC DETERMINATION OF ONDANSETRON BY ION-PAIR FORMATION WITH BROMOCRESOL GREEN

Authors
ZAMORA LL CALATAYUD JM
Citation
Ll. Zamora et Jm. Calatayud, EXTRACTIVE SPECTROPHOTOMETRIC DETERMINATION OF ONDANSETRON BY ION-PAIR FORMATION WITH BROMOCRESOL GREEN, Analytical letters, 29(5), 1996, pp. 785-792
Citations number
9
Categorie Soggetti
Chemistry Analytical
Journal title
Analytical letters → ACNP
ISSN journal
00032719
Volume
29
Issue
5
Year of publication
1996
Pages
785 - 792
Database
ISI
SICI code
0003-2719(1996)29:5<785:ESDOOB>2.0.ZU;2-D
Abstract
An empirical spectrophotometric procedure for the determination of the antiemetic ondansetron is carried out. The method is based on the for mation of a 1:1 ion pair with bromocresol green in the pH range over 3 .2 - 4.4, extraction into chloroform layer and spectrophotometric meas urement at 420.8 nm. The calibration graph is linear over the range 0. 1 - 20 mu g ml(-1) ondansetron, with a relative standard deviation of 2.7%; the influence of foreign substances is also studied. The method is applied to ondansetron determination in human urine.