Pe. Ceccaldi et al., RABIES VIRUS SELECTIVELY ALTERS 5-HT(1) RECEPTOR SUBTYPES IN RAT-BRAIN, European journal of pharmacology. Molecular pharmacology section, 245(2), 1993, pp. 129-138
Rabies virus infection in man induces a series of clinical symptoms, s
ome suggesting involvement of the central serotonergic system. The res
ults of the present study show that, 5 days after rabies virus infecti
on in rat, the total reversible high-affinity binding of [H-3]5-HT in
the hippocampus is not affected, suggesting that 5-HT1A binding is not
altered. 5-HT1B sites identified by [I-125]cyanopindolol binding are
not affected in the cortex 3 and 5 days after the infection. According
ly, the cellular inhibitory effect of trifluoromethylphenylpiperazine
(TFMPP) on the [H-3]acetylcholine-evoked release, presumably related t
o 5-HT1B receptor activity, is not modified 3 days after infection. In
contrast, [H-3]5-HT binding determined in the presence of drugs maski
ng 5-HT1A, 5-HT1B and 5-HT1C receptors, is markedly (50%) reduced 3 da
ys after the viral infection. These results suggest that 5-HT1D-like r
eceptor subtypes may be affected specifically and at an early stage af
ter rabies viral infection.