OPTIMIZATION OF A GRANULATION PROCEDURE FOR A HYDROPHILIC MATRIX TABLET USING EXPERIMENTAL-DESIGN

Authors
BOUCKAERT S MASSART DL MASSART B REMON JP
Citation
S. Bouckaert et al., OPTIMIZATION OF A GRANULATION PROCEDURE FOR A HYDROPHILIC MATRIX TABLET USING EXPERIMENTAL-DESIGN, Drug development and industrial pharmacy, 22(4), 1996, pp. 321-327
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Drug development and industrial pharmacy → ACNP
ISSN journal
03639045
Volume
22
Issue
4
Year of publication
1996
Pages
321 - 327
Database
ISI
SICI code
0363-9045(1996)22:4<321:OOAGPF>2.0.ZU;2-T
Abstract
An experimental design was used in order to optimize a granulation pro cedure in a high-shear miter for a hydrophilic matrix tablet formulati on. The parameters tested were the amount of water in the hydroalcohol ic granulation liquid, the amount of granulation liquid, and the massi ng time. The amount of granulation liquid was the most important param eter, followed by the amount of water in the granulation liquid. The i nfluence of the massing time was negligible. A granule with a friabili ty below 20% was obtained.