ONE-STAGE MONOSUBSTITUTION IN CYCLEN - 2 NOVEL EXAMPLES

Authors
FORMANOVSKY AA MIKHURA IV
Citation
Aa. Formanovsky et Iv. Mikhura, ONE-STAGE MONOSUBSTITUTION IN CYCLEN - 2 NOVEL EXAMPLES, Synthetic communications, 26(8), 1996, pp. 1595-1603
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
26
Issue
8
Year of publication
1996
Pages
1595 - 1603
Database
ISI
SICI code
0039-7911(1996)26:8<1595:OMIC-2>2.0.ZU;2-P
Abstract
Two new routes for alkylsubstituton of one in four amino groups in 1,4 ,7,10-tetraazacyclododecane (cyclen) are described, isomeric N-tris(hy droxy)butylcyclens 4 and 6 have been obtained in very good yields. Fur ther carboxymethylation of other three amino groups afforded ris(hydro xy)butyl-1,4,7-tris(carboxymethyl)cyclens 1 and 2.