IMPROVEMENT OF THE SYNTHESIS OF CHIRAL NON-RACEMIC BICYCLIC LACTAMS IN THE PIPERIDIN-2-ONES SERIES

Authors
MICOUIN L QUIRION JC HUSSON HP
Citation
L. Micouin et al., IMPROVEMENT OF THE SYNTHESIS OF CHIRAL NON-RACEMIC BICYCLIC LACTAMS IN THE PIPERIDIN-2-ONES SERIES, Synthetic communications, 26(8), 1996, pp. 1605-1611
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
26
Issue
8
Year of publication
1996
Pages
1605 - 1611
Database
ISI
SICI code
0039-7911(1996)26:8<1605:IOTSOC>2.0.ZU;2-B
Abstract
Bicyclic lactams 8 have been prepared in enantiomerically pure form fr om the corresponding amino esters 5 and glutaric anhydride. The key st ep is the reduction of imides 7 in methanol. Selective reduction of 8 furnished N-substituted lactams 9.