A NOVEL SYNTHESIS OF THE ANTIPSYCHOTIC AGENT ZIPRASIDONE

Authors
URBAN FJ BREITENBACH R GONYAW D
Citation
Fj. Urban et al., A NOVEL SYNTHESIS OF THE ANTIPSYCHOTIC AGENT ZIPRASIDONE, Synthetic communications, 26(8), 1996, pp. 1629-1638
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
26
Issue
8
Year of publication
1996
Pages
1629 - 1638
Database
ISI
SICI code
0039-7911(1996)26:8<1629:ANSOTA>2.0.ZU;2-Q
Abstract
A new synthesis of the antipsychotic ziprasidone from 2,5-dichloro-4-n itrotoluene 3 is presented. The nitro group in 3 was used to activate the orthochlorine for displacement and the methyl group for enamine fo rmation and introduction of the piperazinyl moiety.