N. Atef et al., A SPECIFIC BETA(3)-ADRENOCEPTOR AGONIST INDUCES INCREASED PANCREATIC-ISLET BLOOD-FLOW AND INSULIN-SECRETION IN RATS, European journal of pharmacology, 298(3), 1996, pp. 287-292
In order to study the role of beta(3)-adrenoceptor stimulation on insu
lin secretion in mts, plasma insulin level and islet blood flow were m
easured during treatment with CL 316243 which is chemically named diso
dium (R, ]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate, a specific
beta(3)-adrenoceptor agonist. CL 316243 induced a marked increase in
both islet blood flow and plasma insulin concentration without changes
in whole pancreatic blood flow. This increase was totally prevented w
hen the rats were pretreated with bupranolol, a beta(1),beta(2),beta(3
)-adrenoceptor antagonist, but not with nadolol, a beta(1),beta(2)-adr
enoceptor antagonist. We conclude that beta(3)-adrenoceptor stimulatio
n provokes a marked vasodilatation of microvessels in the islets of La
ngerhans, which in turn could contribute to the increase in insulin se
cretion.