ENZYMURIA AS A MARKER OF EARLY RENAL DAMA GE IN PSORIASIS AND DIABETES-MELLITUS

The activity of gamma-glutamyl transferase (GGT), alkaline phosphatase (AP), lactate dehydrogenase (LDG), N-acetyl-beta-D-glucosaminidase (N AG) was assessed in 53 patients with psoriasis (PS), 24 PS patients wi th affected kidneys, 50 patients with type 1 diabetes mellitus(DM). En hanced activity of the enzymes occurred not only in nephropathy patien ts but also in those without proteinuria. AP and NAG were more active in PS, while LDG and NAG in DM. Both in PS and DM, NAG activity rose 3 -4-fold compared to control. A direct correlation was found between en zymuria and uremia, glycemia (in hyperglycemia only) and cholesterolem ia. An inverse relationship existed between enzymuria and uricosuria. The above changes in enzymic activity are attributed to impairment of tubules of the kidney induced by PS and DM. Diagnostic significance of enzymuria as a marker of early tubular involvement is confirmed by in vestigations of renal biopsies.