G-PROTEIN-GATED K+ CHANNEL (GIRK1) PROTEIN IS EXPRESSED PRESYNAPTICALLY IN THE PARAVENTRICULAR NUCLEUS OF THE HYPOTHALAMUS

Authors
MORISHIGE K INANOBE A TAKAHASHI N YOSHIMOTO Y KURACHI H MIYAKE A TOKUNAGA Y MAEDA T KURACHI Y
Citation
K. Morishige et al., G-PROTEIN-GATED K+ CHANNEL (GIRK1) PROTEIN IS EXPRESSED PRESYNAPTICALLY IN THE PARAVENTRICULAR NUCLEUS OF THE HYPOTHALAMUS, Biochemical and biophysical research communications, 220(2), 1996, pp. 300-305
Citations number
27
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
220
Issue
2
Year of publication
1996
Pages
300 - 305
Database
ISI
SICI code
0006-291X(1996)220:2<300:GKC(PI>2.0.ZU;2-6
Abstract
We prepared a specific antibody against GIRK1, the major subunit of th e G protein-gated K+ (K-G) channel. Immunohistochemical study revealed that GIRK1 immunoreactivity was detected in thr presynaptic, but not in the postsynaptic, region in the paraventricular nucleus of the rat hypothalamus (PVN). Therefore, activation of the K-G channel may under lie presynaptic inhibition of neurotransmitter release by various agon ists, such as dopamine, noradrenaline, opioids, and histamine, in PVN. (C) 1996 Academic Press, Inc.