CALCULATION OF THE PLASMA DRUG LEVEL WITH ORAL CONTROLLED-RELEASE DOSAGE FORMS - EFFECT OF THE DOSE FREQUENCY

Calculation has been made for determining the drug level-time history in the plasma compartment in the case of oral dosage forms with releas e controlled by diffusion. Some emphasis has been placed upon the freq uency of multiple administration. A dimensionless number with the amou nt of drug as a fraction of the amount of drug initially in the dosage form was used. The case of aspirin was considered as the rate constan t of elimination is rather high, leading to great interest for drug de livery with controlled release systems.