Em. Ouriemchi et Jm. Vergnaud, CALCULATION OF THE PLASMA DRUG LEVEL WITH ORAL CONTROLLED-RELEASE DOSAGE FORMS - EFFECT OF THE DOSE FREQUENCY, International journal of pharmaceutics, 127(2), 1996, pp. 177-184
Calculation has been made for determining the drug level-time history
in the plasma compartment in the case of oral dosage forms with releas
e controlled by diffusion. Some emphasis has been placed upon the freq
uency of multiple administration. A dimensionless number with the amou
nt of drug as a fraction of the amount of drug initially in the dosage
form was used. The case of aspirin was considered as the rate constan
t of elimination is rather high, leading to great interest for drug de
livery with controlled release systems.