CIPROFLOXACIN DETERMINATION BY VISIBLE-LIGHT SPECTROPHOTOMETRY USING IRON(III)NITRATE

A simple, rapid, efficient and inexpensive method was developed for th e determination of ciprofloxacin in tablets and in solutions for infus ion by visible light spectrophotometry using 1% iron(III)nitrate in 1% nitric acid. The complex formed by the iron(III)nitrate solutions and the sample and standard ciprofloxacin solutions gave origin to a comp ound of yellow-orange colour with maximum absorption at 435 nm, which was stable for 60 min. The Lambert-Beer law was obeyed in the concentr ation range of 20-100 mu g/ml. The spectrophotometric method proposed for the evaluation of ciprofloxacin as a raw material and in tablets a nd solution for infusion is a good alternative method to that recommen ded by USP XXIII.