NEW INSIGHTS REGARDING THE POTENTIAL OF THE PRONUCLEOTIDE APPROACH INANTIVIRAL CHEMOTHERAPY

Authors
GOSSELIN G GIRARDET JL PERIGAUD C BENZARIA S LEFEBVRE I SCHLIENGER N POMPON A IMBACH JL
Citation
G. Gosselin et al., NEW INSIGHTS REGARDING THE POTENTIAL OF THE PRONUCLEOTIDE APPROACH INANTIVIRAL CHEMOTHERAPY, Acta Biochimica Polonica, 43(1), 1996, pp. 195-208
Citations number
31
Categorie Soggetti
Biology
Journal title
Acta Biochimica Polonica → ACNP
ISSN journal
0001527X
Volume
43
Issue
1
Year of publication
1996
Pages
195 - 208
Database
ISI
SICI code
0001-527X(1996)43:1<195:NIRTPO>2.0.ZU;2-6
Abstract
The rationale for a pronucleotide approach based on the use of phospho triesters which incorporate enzyme-mediated bio-labile protection is d iscussed in detail. Among the studied bio-labile phosphate protecting groups, the S-acyl-2-thioethyl (SATE) groups appeared the most promisi ng as exemplified in cell culture systems in the case of the pronucleo tides of 3'-azido-3'-deoxythymidine, 2'3'-didehydro-3'-deoxythymidine, 2'3'-dideoxyadenosine and acyclovir. In vivo implementations of such bis(SATE) pronucleotides have been planned for future animal studies.