A NEW FACILE PROCEDURE FOR THE PREPARATION OF PYRROLO[2,1-C] [1,4]BENZODIAZEPINES - SYNTHESIS OF THE ANTIBIOTIC DC-81 AND ITS THIO ANALOGUE

Authors
KAMAL A REDDY BSP REDDY BSN
Citation
A. Kamal et al., A NEW FACILE PROCEDURE FOR THE PREPARATION OF PYRROLO[2,1-C] [1,4]BENZODIAZEPINES - SYNTHESIS OF THE ANTIBIOTIC DC-81 AND ITS THIO ANALOGUE, Tetrahedron letters, 37(13), 1996, pp. 2281-2284
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
13
Year of publication
1996
Pages
2281 - 2284
Database
ISI
SICI code
0040-4039(1996)37:13<2281:ANFPFT>2.0.ZU;2-E
Abstract
An efficient synthesis of the imine form of the pyrrolo[2,1-c] [1,4] b enzodiazepine ring system based on a new reductive cyclization procedu re is described. The naturally occuring antibiotic DC-81(5c) and its 5 -thio analogue (7c) have also been synthesized to illustrate the usefu lness of this methodology.