MODELING STUDIES ON THE TRANSIENT AND STEADY-STATE BEHAVIOR OF A SIMULATED COUNTERCURRENT CHROMATOGRAPHIC SYSTEM

A simulated counter-current chromatographic (SCC) separation process i s simulated using a dispersed plug flow model with a direct approach. The solution of the governing partial differential equations is solved with a numerical technique based on the method of orthogonal collocat ion. Mass transfer resistances and axial dispersion are accounted for in the model. This model is used to simulate the separation of praziqu antel enantiomers in the SCC system. The model accounts fully the sequ ential operation of the system. The transient and steady state behavio ur of the separation of praziquantel enantiomers by this chromatograph ic system can be described adequately by this model.