THERMODYNAMIC TREATMENT OF LIGAND-RECEPTOR INTERACTIONS

This work reports the development of a physico-chemical model for liga nd-receptor interactions. It considers receptors having groups of diff erent binding sites in equilibrium and far from equilibrium where each of these may have multiple occupancies. The obtained results under ap propriate simplifications give the well known Scatchard, Hill and Adai r relations and provide a very interesting tool for studying receptor- ligand phenomena and for determining the related parameters and intera ction energies.