REGIONALLY SPECIFIC INDUCTION OF ICE MESSENGER-RNA AND ENZYME-ACTIVITY IN THE RAT-BRAIN AND ADRENAL-GLAND BY LPS

Authors
TINGSBORG S ZETTERSTROM M ALHEIM K HASANVAN H SCHULTZBERG M BARTFAI T
Citation
S. Tingsborg et al., REGIONALLY SPECIFIC INDUCTION OF ICE MESSENGER-RNA AND ENZYME-ACTIVITY IN THE RAT-BRAIN AND ADRENAL-GLAND BY LPS, Brain research, 712(1), 1996, pp. 153-158
Citations number
32
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
712
Issue
1
Year of publication
1996
Pages
153 - 158
Database
ISI
SICI code
0006-8993(1996)712:1<153:RSIOIM>2.0.ZU;2-G
Abstract
Pro interleukin-1 beta converting enzyme (ICE) activity in the pituita ry was found to be significantly increased 4 h after intraperitoneal i njection of E. coli lipopolysaccharides, when distribution and inducib ility of the enzyme was studied in the adult rat brain and the adrenal gland, using an artificial fluorescence peptide substrate. The same l ipopolysaccharide treatment induced ICE mRNA levels in the pituitary, adrenal gland and hypothalamus as studied by reverse transcript-polyme rase chain reaction.