HYPERCOAGULABILITY IN CANCER

This type of thrombotic microangiopathy more commonly resembles the he molytic-uremic syndrome (HUS) than thrombotic thrombocytopenic purpura (TTP). The syndrome has been associated with the use of cyclosporin, mitomycin C, combinations of other chemotherapeutic and immunosuppress ive agents, and total body irradiation. Endothelial cell injury and vo n Willebrand factor may be involved in pathogenesis of the intravascul ar platelet aggregation and tissue (especially renal) ischemia and inf arction that characterize the entity. The most effective therapy for t hrombotic microangiopathy associated with drugs and bone marrow transp lantation has not been determined.