COMPARISON OF CEPHALORIDINE RENAL ACCUMULATION AND URINARY-EXCRETION BETWEEN NORMOGLYCEMIC AND DIABETIC ANIMALS

The renal toxicity of cephaloridine is reduced in a streptozotocin dia betic rat model. This study tested the hypothesis that renal cortical cephaloridine accumulation was diminished in diabetic rats. The follow ing studies also investigated whether renal excretion was enhanced in diabetic rats. Male Fischer 344 rats were randomly divided into normog lycemic or diabetic groups. Diabetes was induced by injection (intrape ritoneal, i.p.) of 35 mg/kg streptozotocin. Normoglycemic and diabetic rats were injected (i.p.) with 1500 mg/kg cephaloridine. Peak plasma cephaloridine levels were similar in both groups. Renal cortical accum ulation was diminished (P < 0.05) in the diabetic group 1 and 4 h afte r cephaloridine injection. Urinary cephaloridine excretion was enhance d (P < 0.05) in the diabetic group relative to the normoglycemic anima ls during the first 4 h after cephaloridine injection. Comparisons bet ween normoglycemic and diabetic groups indicated renal cortical cephal oridine accumulation was lower in the diabetic group. These findings w ould support the hypothesis that reduced cephaloridine toxicity in dia betic animals was due to reduced renal cortical accumulation of the to xin. These data also demonstrate that cephaloridine excretion was enha nced in the diabetic group and may contribute to the diminished renal accumulation.