NIMODIPINE REDUCTION OF NALTREXONE-PRECIPITATED LOCUS-COERULEUS ACTIVATION AND ABSTINENCE BEHAVIOR IN MORPHINE-DEPENDENT RATS

Authors
KRYSTAL JH COMPERE S NESTLER EJ RASMUSSEN K
Citation
Jh. Krystal et al., NIMODIPINE REDUCTION OF NALTREXONE-PRECIPITATED LOCUS-COERULEUS ACTIVATION AND ABSTINENCE BEHAVIOR IN MORPHINE-DEPENDENT RATS, Physiology & behavior, 59(4-5), 1996, pp. 863-866
Citations number
31
Categorie Soggetti
Psychology, Biological","Behavioral Sciences",Physiology
Journal title
Physiology & behavior → ACNP
ISSN journal
00319384
Volume
59
Issue
4-5
Year of publication
1996
Pages
863 - 866
Database
ISI
SICI code
0031-9384(1996)59:4-5<863:NRONLA>2.0.ZU;2-9
Abstract
Single-unit recordings in anesthetized animals revealed that the L-typ e calcium channel antagonist, nimodipine (10 mg/kg), attenuated the ac tivation of locus coeruleus neurons produced by naltrexone in opiate-d ependent rats. Nimodipine also dose-dependently (1 mg/kg, 10 mg/kg, IP ) inhibited the display of naloxone-precipitated withdrawal behaviors with a time course similar to that of nimodipine effects on the locus coeruleus. These data suggest that nimodipine may suppress opiate with drawal via noradrenergic mechanisms.