R. Sartori et al., THE NOVEL USE OF RH(I) COMPLEXES WITH NAPHTHYRIDINE LIGANDS AND POLY(OXYETHYLENE) AS ANTITUMORALS, Anti-cancer drugs, 7(1), 1996, pp. 87-92
Rh(I) complexes adsorbed on polymers, as a way to improve their transp
ort and solubility properties, were studied as antitumor agents, The b
inding constants of the complexes to the polymer were evaluated in ord
er to determine the conditions for maximum association to the vehicle,
The toxicity of the pure complexes and those bound were determined in
vivo using female mice, [Rh(NBD)(2,4N)]ClO4, complex A; where NBD=nor
bornadiene, (3,4N) = 3,3'-dimethylene-2,2'-di-1,8-naphthyridine, was i
nvestigated on primary solid tumors and ascitic tumors, [Rh(NBD)(3,4N)
]ClO4, complex B; where (3,4N) = 3,3'-trimethylene-2,2'-di-1,8-naphthy
ridine, was investigated on ascitic tumors, These Rh(I) complexes appe
ar to be promising drugs because of their solubility in aqueous polyme
r, which make them easier to handle in comparison with the neutral spe
cies, These complexes show a similarity to cisplatin by reducing tumor
growth and by increasing the survival life span of mice, Poly (oxyeth
ylene) was used to solubilize these poorly water-soluble compounds and
to stabilize the compounds in the solution before injection, These st
udies suggest that both complexes, A and B, are good candidates for tu
mor control growth and increase the survival time.