STUDIES OF MIXED-LIGAND COMPLEXES OF CHLOROGLYCYL-D,L-METHIONINATO-PLATINUM(II) AND CHLOROGLYCYL-D,L-METHIONINATOPALLADIUM(II) WITH PURINESAND NUCLEOSIDES

The binary complex chloroglycyl-D,L-methioninatoplatinum(II) was synth esised and characterised. Subsequently, mixed ligand complexes of chlo roglycyl-D,L-methioninatoplatinum(II) and chloroglycyl-D,L-methioninat opalladium(II) with purines adenine, guanine, hypoxanthine, and nucleo sides adenosine, guanosine, inosine and cytidine were synthesised and characterised. Based on spectroscopic data it was found that adenine ( Pt and Pd complexes), hypoxanthine (Pt), adenosine (Pt and Pd) and ino sine (Pt) form binuclear complexes. Adenine coordinates through N-1 an d N-7 in Pt complex and through N-1 and N-7 in the Pt complex, whereas hypoxanthine coordinates through N-3 and N-9 in the Pt complex. The c orresponding Pd complex is insoluble. Adenosine (Pt and Pd) and inosin e (Pt) coordinate through N-1 and N-7. Guanine, guanosine and cytidine form mononuclear complexes, the first two ligands coordinating to the metal ion through N-7 and the third (cytidine) through N-3.