A PANCREATIC ENDOCRINE TUMOR ARISING WITHIN A SEROUS CYSTADENOMA OF THE PANCREAS

We report a pancreatic endocrine tumor arising within an otherwise ben ign pancreatic serous cystadenoma in a 47-year-old woman with a histor y of lupus treated by steroids. She presented 10 years before resectio n with epigastric pain and intermittent jaundice. Histologic and immun ohistochemical studies showed that the solid endocrine component was c omposed of small, uniform cells with stippled nuclei, which were chrom ogranin A positive. The surrounding cystic component was lined by peri odic acid Schiffs-positive, diastase-digestable cells containing glyco gen. To the best of our knowledge, this is the first case of a serous cystadenoma of the pancreas that contains a well defined pancreatic en docrine tumor reported in the English literature.