Smokeless tobacco practices are common in some ports of the world and
the use seems to be increasing. Nicotine exposure is similar in smokel
ess tobacco users and smokers, often leading to strong physical depend
ence. As a rule, smokeless tobacco products contain high levels of nit
rosamines with carcinogenic potency in experimental animals. Habitual
use of oral tobacco can increase the risk of oral cancer, but the data
ore insufficient to assess in detail the risks associated with many t
ypes of smokeless tobacco. A recent study suggests that smokeless toba
cco use is related to cardiovascular disease, which could be of great
public health importance. The known and suspected health risks associa
ted with the use of smokeless tobacco provide a basis for preventive a
ction. In particular, efforts are needed to limit the introduction of
such practices among young people, which may serve as a gateway to smo
king.