ISLET-CELL AND GLUTAMIC-ACID DECARBOXYLASE ANTIBODIES AND HEAT-SHOCK-PROTEIN-65 RESPONSES IN CHILDREN WITH NEWLY-DIAGNOSED INSULIN-DEPENDENT DIABETES-MELLITUS
T. Scheinin et al., ISLET-CELL AND GLUTAMIC-ACID DECARBOXYLASE ANTIBODIES AND HEAT-SHOCK-PROTEIN-65 RESPONSES IN CHILDREN WITH NEWLY-DIAGNOSED INSULIN-DEPENDENT DIABETES-MELLITUS, Immunology letters, 49(1-2), 1996, pp. 123-126
Islet cell antibodies (ICA) were detected in 66% and glutamic acid dec
arboxylase (GAD) antibodies in 64% of children (n = 47) with newly dia
gnosed insulin-dependent diabetes mellitus (IDDM). Fifteen percent of
the patients had neither GAD nor ICA antibodies. Responses to mycobact
erial heat-shock protein 65 (Hsp65) were detected in all patients. The
re was a significant correlation between anti-GAD antibodies and proli
feration of peripheral blood mononuclear cells to Hsp65, and between I
CA and antibodies to Hsp65.