ISLET-CELL AND GLUTAMIC-ACID DECARBOXYLASE ANTIBODIES AND HEAT-SHOCK-PROTEIN-65 RESPONSES IN CHILDREN WITH NEWLY-DIAGNOSED INSULIN-DEPENDENT DIABETES-MELLITUS

Islet cell antibodies (ICA) were detected in 66% and glutamic acid dec arboxylase (GAD) antibodies in 64% of children (n = 47) with newly dia gnosed insulin-dependent diabetes mellitus (IDDM). Fifteen percent of the patients had neither GAD nor ICA antibodies. Responses to mycobact erial heat-shock protein 65 (Hsp65) were detected in all patients. The re was a significant correlation between anti-GAD antibodies and proli feration of peripheral blood mononuclear cells to Hsp65, and between I CA and antibodies to Hsp65.