A. Carvajal et al., ASPIRIN OR ACETAMINOPHEN - A COMPARISON FROM DATA COLLECTED BY THE SPANISH DRUG-MONITORING SYSTEM, Journal of clinical epidemiology, 49(2), 1996, pp. 255-261
Citations number
43
Categorie Soggetti
Public, Environmental & Occupation Heath","Medicine, General & Internal
To characterize and compare the toxicity profiles of aspirin and aceta
minophen when used by large populations, all records of adverse drug r
eactions to these drugs reported to the Spanish Drug Monitoring System
from 1982 to 1991 were analyzed. According to these data, aspirin ind
uced reactions were more serious than those reactions to acetaminophen
; the severity of all the reactions in both cases was associated with
time of exposure and with the accumulated dose administered. For GI re
actions to aspirin no association was found between severity and time
of exposure or dose, although an association with age was found. There
were no differences between the proportions of deaths, malformations,
and renal damage recorded for either of the two groups. Proportions o
f hematological and hepatic disturbances were greater with acetaminoph
en. Adverse drug reaction data for aspirin and acetaminophen from spon
taneous reporting seem to be consistent with data coming from observat
ional studies.