RACIAL-DIFFERENCES IN SKIN PATHOPHYSIOLOGY

Racial differences in skin function occur and may be responsible for d ifferences in skin reactivity in physiologic and pathologic conditions . This article reviews the main racial anatomic and physiologic differ ences as well as mechanisms of irritation, sensitization, and drug abs orption reported in the recent literature. Racial differences in trans cutaneous penetration of chemicals and drug absorption have been descr ibed. Decreased transcutaneous penetration has been reported in black persons. In contrast, conflicting findings have been reported concerni ng some aspects of irritation and sensitization. Decreased erythematou s reactions have been found in pigmented skin, whereas white persons h ave a stronger resistance to water barrier damage. Regional variation in skin function is more evident in fair skin because of the modifying effects of long-term UV exposure.