THE NOVEL 6-(N-PYRROLYL)PURINE ACYCLIC NUCLEOSIDES - H-1 AND C-13 NMRAND X-RAY STRUCTURAL STUDY

Synthesis of the novel nucleoside analogues containing exocyclic pyrro lo moiety and acyclic side chains attached to the purine ring at N-9 a nd N-7 is described. The site of alkylation was determined by H-1 and C-13 NMR on the basis of chemical shifts, C-H coupling constants and c onnectivity in NOESY and HETCOR spectra. The N-9 substitution of 7 was proved by its X-ray crystallographic analysis.