HYALURONAN-BINDING PROPERTIES OF HUMAN SERUM HEMOPEXIN

Hemopexin, the heme-binding serum glycoprotein, exhibits a complex ele ctrophoretic pattern on two-dimensional immunoelectrophoresis on agaro se gels into which hyaluronic acid is incorporated in the first and mo nospecific anti-hemopexin in the second dimension. This heterogeneity reflects a range of interactions of hemopexin isoforms with hyaluronic acid. Electrophoretic patterns of individual human sera greatly diffe r in their contents of hyaluronan-interacting hemopexin species. Hemop exin itself has no hyaluronidase activity.