Jh. Okeefe et al., LOVASTATIN PLUS PROBUCOL FOR PREVENTION OF RESTENOSIS AFTER PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY, The American journal of cardiology, 77(8), 1996, pp. 649
We hypothesized that combination therapy inc luding lovastatin (for lo
w-density lipoprotein [LDL] lowering) and probucol (for antioxidant ac
tivity) may be useful in reducing or preventing restenosis and recurre
nt coronary events after percutaneous transluminal coronary angioplast
y (PTCA). The Angioplasty Plus Probucol/Lovastatin Evaluation (APPLE)
trial was designed to test this hypothesis.