SIGNIFICANT EFFECT OF ACYL-GROUPS ON ENANTIOSELECTIVITY IN LIPASE-CATALYZED TRANSESTERIFICATIONS

Authors
EMA T MAENO S TAKAYA Y SAKAI T UTAKA M
Citation
T. Ema et al., SIGNIFICANT EFFECT OF ACYL-GROUPS ON ENANTIOSELECTIVITY IN LIPASE-CATALYZED TRANSESTERIFICATIONS, Tetrahedron : asymmetry, 7(3), 1996, pp. 625-628
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
7
Issue
3
Year of publication
1996
Pages
625 - 628
Database
ISI
SICI code
0957-4166(1996)7:3<625:SEOAOE>2.0.ZU;2-2
Abstract
The effect of the acyl group of acylating agents on the enantioselecti vity in the lipase-catalyzed transesterifications of racemic [(N,N-dim ethylcarbamoyl)methyl]-3-cyclopenten-1-ol in diisopropyl ether was fou nd to be significant. The enantioselectivity was enhanced markedly by changing the acylating agent from vinyl acetate to vinyl butyrate, and dropped substantially with longer acyl donors. Other acyl donors were also examined. (C) 1996 Published by Elsevier Science Ltd