SYNTHESIS OF YLAMINO)-1-HYDROXYBUTYL]PHENYL]METHANESULFONAMIDE, (E)-2-BUTENEDIOATE (2 1) SALT (ARTILIDE FUMARATE) AND THE ENANTIOMERS OF YLAMINO)-1-HYDROXYBUTYL]PHENYL]METHANESULFONAMIDE, (E)-2-BUTENEDIOATE (2/1) SALT (IBUTILIDE FUMARATE)/

Authors
PERRICONE SC CHIDESTER CG HESTER JB
Citation
Sc. Perricone et al., SYNTHESIS OF YLAMINO)-1-HYDROXYBUTYL]PHENYL]METHANESULFONAMIDE, (E)-2-BUTENEDIOATE (2 1) SALT (ARTILIDE FUMARATE) AND THE ENANTIOMERS OF YLAMINO)-1-HYDROXYBUTYL]PHENYL]METHANESULFONAMIDE, (E)-2-BUTENEDIOATE (2/1) SALT (IBUTILIDE FUMARATE)/, Tetrahedron : asymmetry, 7(3), 1996, pp. 677-690
Citations number
29
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
7
Issue
3
Year of publication
1996
Pages
677 - 690
Database
ISI
SICI code
0957-4166(1996)7:3<677:SOY(>2.0.ZU;2-7
Abstract
Syntheses of artilide fumarate, its (S) enantiomer and the (R) and (S) enantiomers of ibutilide fumarate were achieved by reduction of the p rochiral ketones with (+) and (-)-B-chlorodiisopinocampheylborane. Sev eral methods for analyzing the optical purity of these compounds are p resented. The absolute configurations were established by a single cry stal X-ray crystallographic analysis of o)-1-hydroxy-4-oxobutyl]phenyl ]methanesulfonamide. (C) 1996 Elsevier Science Ltd